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just before use, Sculptra needs to be reconstituted with 5ml of h2o for at least two hours. Sculptra is then injected in the deep dermal layer or subcutaneous layer, using a 26G needle (NOT INCLUDED) as well as the cross-hatch method. Use at the internet site of pores and skin sores, cysts, pimples, rashes, hives or infection really should be post